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M9650945.TXT
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1996-03-30
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Document 0945
DOCN M9650945
TI Intestinal microsporidiosis with Septata intestinalis in a patient with
AIDS--response to albendazole.
DT 9505
AU Franzen C; Muller A; Schwenk A; Salzberger B; Fatkenheuer G; Mahrle G;
Diehl V; Schrappe M; Department of Internal Medicine I, University of
Cologne,; Germany.
SO J Infect. 1995 Nov;31(3):237-9. Unique Identifier : AIDSLINE
MED/96163971
AB Microsporidiosis is a common finding in HIV-infected patients who have
diarrhoea. The species most commonly causing gastrointestinal disease is
Enterocytozoon bieneusi. Recently Septata intestinalis has been
described as a cause of diarrhoea and disseminated infection in patients
with AIDS. A 44-year-old homosexual man with severe immunodeficiency
(CD4 cell count 40/microliters) had a history of watery diarrhoea for 2
weeks. Microsporidian spores measuring 1.2 to 1.5 x 2.5 to 3.0 microns
were found in stool samples. Electron microscopy of duodenal biopsies
confirmed the diagnosis of intestinal microsporidiosis and showed
parasitophorous vacuoles with the typical ultrastructure of S.
intestinalis. The patient was treated with albendazole (400 mg twice
daily) and became asymptomatic within 4 days. No spores could be
detected in stool samples after a treatment period of 14 days. About 25
infections with S. intestinalis have been reported to date, and the case
presented here is the first in a German patient.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult
Albendazole/*THERAPEUTIC USE Animal Anthelmintics/*THERAPEUTIC USE
AIDS-Related Opportunistic Infections/DRUG THERAPY/*PARASITOLOGY Case
Report Diarrhea/DRUG THERAPY/*PARASITOLOGY Homosexuality, Male Human
Male Microscopy, Electron Microspora/GROWTH &
DEVELOPMENT/*ULTRASTRUCTURE Microspora Infections/DRUG
THERAPY/*PARASITOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).